My complete bilbiography is available on MyNCBI.

(1)   Point, V., Achache, W., Laudouze, J., Sepulveda Ramos, E., Maziero, M., Crauste, C., Canaan, S., & Santucci, P*. (2025). Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems. FEBS Open Bio, 10.1002/2211-5463.70172. Advance online publication. https://doi.org/10.1002/2211-5463.70172  Research Article * Corresponding author

(2)   Laudouze, J., Rokitskaya, T. I., Abolet, A., Point, V., Firsov, A. M., Khailova, L. S., Cavalier, J. F., Canaan, S., Baulard, A. R., Antonenko*#, Y. N., Gouzy*#, A., & Santucci*#, P. (2025). Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification. bioRxiv : the preprint server for biology, 2025.09.26.678883. https://doi.org/10.1101/2025.09.26.678883   Research Article * Corresponding authors # Co-senior authors 

(3)   Avellan, R., Lehoux, J., Francis, T., Dargham, T., Celik, L., Guy, A., Poncin, I., Point, V., Kremer, L., Durand, T., Audebert, S., Camoin, L., Spilling, C., Santucci, P., Crauste, C., Canaan, S., & Cavalier, J. F. (2025). Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes. ACS infectious diseases, 11(6), 1589–1605. https://doi.org/10.1021/acsinfecdis.5c00127  Research Article 

(4)   Santucci*, P., & Tsagakis*, I. (2025). An open chat with…Pierre Santucci: a testimonial on why we should engage with scientific societies and their journals. FEBS Open Bio, 15(6), 894–897. https://doi.org/10.1002/2211-5463.70045  * Corresponding authors

(5)   Dargham, T., Aguilera-Correa, J. J., Avellan, R., Mallick, I., Celik, L., Santucci, P., Brasseur, G., Poncin, I., Point, V., Audebert, S., Camoin, L., Daher, W., Cavalier, J.-F., Kremer, L., & Canaan, S. (2025). A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria. mBio, e0147524. Advance online publication. https://doi.org/10.1128/mbio.01475-24 Research Article

(6)   Laudouze, J., Canaan, S., Gouzy*#, A., & Santucci*#, P. (2025). Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms. FEBS letters, 10.1002/1873-3468.70023. Advance online publication. https://doi.org/10.1002/1873-3468.70023 Review * Corresponding authors # Co-senior authors

(7)   Laudouze, J., Francis, T., Forest, E., Mies, F., Bolla, J-M., Crauste, C., Canaan, S., Shlyonsky#*, V., Santucci#*, P., & Cavalier#*, J-F. (2024). Anti-tubercular potential and pH-driven mode of action of salicylic acid derivatives. FEBS open bio, 10.1002/2211-5463.13944. Advance online publication. https://doi.org/10.1002/2211-5463.13944 Research Article. * Corresponding authors # Co-senior authors

(8)   Sarrazin, M., Poncin, I., Fourquet, P., Audebert, S., Camoin, L., Denis, Y., Santucci, P., Spilling, C. D., Kremer, L., Moigne, V. L., Herrmann, J. L., Cavalier, J. F., & Canaan, S. (2024). Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus. Journal of biomedical science, 31(1), 103. https://doi.org/10.1186/s12929-024-01091-w Research Article. 

(9)   Laudouze, J., Point, V., Achache, W., Crauste, C., Canaan, S., & Santucci, P.* (2024). Fluorescence-based CRISPR interference system for controlled genetic repression and live single-cell imaging in mycobacteria. FEBS letters, 10.1002/1873-3468.15071. Advance online publication. https://doi.org/10.1002/1873-3468.15071 Research Article. * Corresponding author 

(10)Santucci, P*. (2024). Molecular Microbiology of Microbiomes. Molecular microbiology, 10.1111/mmi.15308. Advance online publication. https://doi.org/10.1111/mmi.15308 Editorial * Corresponding author

(11)Day, N. J., Santucci, P., & Gutierrez, M. G. (2024). Host cell environments and antibiotic efficacy in tuberculosis. Trends in microbiology, 32(3), 270–279. https://doi.org/10.1016/j.tim.2023.08.009 Review

(12)Dargham, T., Mallick, I., Kremer, L., Santucci*#, P., & Canaan*#, S. (2023). Intrabacterial lipid inclusion-associated proteins: A core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis. FEBS open bio, 10.1002/2211-5463.13721. Advance online publication. https://doi.org/10.1002/2211-5463.13721 Research Article * Corresponding author # Contributed equally

(13)Kandolo, O., Cherrak, Y., Filella-Merce, I., Le Guenno, H., Kosta, A., Espinosa, L., Santucci, P., Verthuy, C., Lebrun, R., Nilges, M., Pellarin, R., & Durand, E. (2023). Acinetobacter type VI secretion system comprises a non-canonical membrane complex. PLoS pathogens, 19(9), e1011687. Advance online publication. https://doi.org/10.1371/journal.ppat.1011687 Research Article

(14)Pellegrino, E., Aylan, B., Bussi, C., Fearns, A., Bernard, E. M., Athanasiadi, N., Santucci, P., Botella, L., & Gutierrez, M. G. (2023). Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages. The Journal of cell biology, 222(12), e202303066. https://doi.org/10.1083/jcb.202303066 Research Article 

(15)Santucci*, P. (2023). Meet early career researcher-Ismath Sadhir-Awardee of the molecular microbiology poster prize at the EMBO workshop bacterial morphogenesis, survival and virulence: Dynamic genomes and envelopes: 06-10 February 2023 | Goa, India. Molecular microbiology, 120(1), 103–104. https://doi.org/10.1111/mmi.15111 Interview * Corresponding author

(16)Aylan, B#., Bernard, E.M#., Pellegrino, E#., Botella, L., Fearns A., Athanasiadi, N., Bussi, C., Santucci, P., & Gutierrez M.G. (2023) Differential control of cytosolic and phagosomal Mycobacterium tuberculosis replication by ATG7 and ATG14 in human macrophages. Nature Microbiology, 8, 803–818 https://doi.org/10.1038/s41564-023-01335-9 Research Article # Contributed equally

(17)Le, T. T. H., Kellenberger, C., Boyer, M., Santucci, P., Flaugnatti, N., Cascales, E., Roussel, A., Canaan, S., Journet, L., & Cambillau, C. (2023). Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model. International journal of molecular sciences, 24(2), 1740. https://doi.org/10.3390/ijms24021740 Research Article

(18)Aylan, B., Botella, L., Gutierrez*#, M.G. & Santucci*#, P(2022). High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages. FEBS Open bio, 10.1002/2211-5463.13537. Advance online publication. https://doi.org/10.1002/2211-5463.13537 Method Article * Corresponding author # Contributed equally 

(19)Bussi, C., Heunis, T., Pellegrino, E., Bernard, E.M., Bah,N., Silva dos Santos, M., Santucci, P., Aylan, B., Rodgers, A., Fearns, A., Mitschke, J., Moore, C., MacRae, J.I., Greco, M., Reinheckel, T., Trost, M., & Gutierrez, M.G. (2022) Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism. Nature Communications, 13(1), 7338. https://doi.org/10.1038/s41467-022-34632-8 Research article 

(20)Santucci*, P., Aylan, B., Botella, L., Bernard, E. M., Bussi, C., Pellegrino, E., Athanasiadi, N., & Gutierrez*, M. G. (2022). Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis. mBio, 13(2), e0011722. https://doi.org/10.1128/mbio.00117-22 Research Article * Corresponding author

(21)Santucci*, P. (2022). Cell wall architecture and function in microbial physiology. Molecular microbiology, 117(4), 715–716. https://doi.org/10.1111/mmi.14892 Editorial * Corresponding author

(22)Santucci, P., Greenwood, D.J., Fearns, T., Chen K., Jiang, H., & Guiterrez, M.G. (2021). Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide. Nature Communications, 12(1), 3816. https://doi.org/10.1038/s41467-021-24127-3 Research Article

(23)Mallick#, I., Santucci#, P., Poncin, I., Point, V., Kremer, L., Cavalier, J.F., & Canaan, S. (2021). Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?. FEMS microbiology reviews, fuab029. Advance online publication. https://doi.org/10.1093/femsre/fuab029 Review # Contributed equally

(24)Santucci*, P. (2021). Intracellular pathogens, membrane damage and cytosolic access. Cellular microbiology, 23(4), e13296. https://doi.org/10.1111/cmi.13296 Editorial

(25)Bernard, E. M., Fearns, A., Bussi, C., Santucci, P., Peddie, C. J., Lai, R. J., Collinson, L. M., & Gutierrez, M. G. (2020). M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion. Journal of cell science, 134(5), jcs252973. https://doi.org/10.1242/jcs.252973 Research Article

(26)Santucci#, P., Johansen#, M. D., Point, V., Poncin, I., Viljoen, A., Cavalier, J. F., Kremer, L., & Canaan, S. (2019). Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria. Scientific reports, 9(1), 8667. https://doi.org/10.1038/s41598-019-45164-5 Research Article # Contributed equally

(27)Santucci, P., Smichi, N., Diomandé, S., Poncin, I., Point, V., Gaussier, H., Cavalier, J. F., Kremer, L., & Canaan, S. (2019). Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains. The FEBS journal, 286(16), 3164–3181. https://doi.org/10.1111/febs.14864 Research Article

(28)Santucci#, P., Dedaki#, C., Athanasoulis, A., Gallorini, L., Munoz, A., Canaan, S., Cavalier, J. F., & Magrioti, V. (2019). Synthesis of Long-Chain β-Lactones and Their Antibacterial Activities against Pathogenic Mycobacteria. ChemMedChem, 14(3), 349–358. https://doi.org/10.1002/cmdc.201800720 Research Article# Contributed equally

(29)Santucci, P., Point, V., Poncin, I., Guy, A., Crauste, C., Serveau-Avesque, C., Galano, J. M., Spilling, C. D., Cavalier, J. F., & Canaan, S. (2018). LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling. Bioscience reports, 38(6), BSR20181953. https://doi.org/10.1042/BSR20181953Research Article

(30)Santucci, P., & Canaan, S. (2018). Lipid Droplets Breakdown: Adipose Triglyceride Lipase Leads the Way. Current protein & peptide science, 19(11), 1131–1133. https://doi.org/10.2174/1389203719666180809143000Commentary

(31)Santucci, P., Diomandé, S., Poncin, I., Alibaud, L., Viljoen, A., Kremer, L., de Chastellier, C., & Canaan, S. (2018). Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages. Infection and immunity, 86(9), e00394-18. https://doi.org/10.1128/IAI.00394-18Research Article

(32)Nguyen#, P. C., Madani#, A., Santucci, P., Martin, B. P., Paudel, R. R., Delattre, S., Herrmann, J. L., Spilling, C. D., Kremer, L., Canaan, S., & Cavalier, J. F. (2018). Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases. International journal of antimicrobial agents, 51(4), 651–654. https://doi.org/10.1016/j.ijantimicag.2017.12.001 Research Article # Contributed equally

(33)Guerrini, V., Subbian, S., Santucci, P., Canaan, S., Gennaro, M. L., & Pozzi, G. (2016). Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage. PloS one, 11(12), e0167989. https://doi.org/10.1371/journal.pone.0167989Research Article

(34)Santucci#, P., Bouzid#, F., Smichi, N., Poncin, I., Kremer, L., De Chastellier, C., Drancourt, M., & Canaan, S. (2016). Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis. Frontiers in cellular and infection microbiology, 6, 122. https://doi.org/10.3389/fcimb.2016.00122 Review # Contributed equally